黄志强是太阳成城集团tyc234cc古天乐助理教授，博士生导师，研究兴趣集中在组织代谢紊乱和营养感知。他于2018年获得卡罗林斯卡太阳成城集团tyc234cc古天乐博士学位（导师Eckardt Treuter），博士后工作与瑞典的Rongrong Fan教授合作研究巨噬细胞极化过程中的表观遗传调控现象。研究利用RNA-seq、GRO-seq、ChIP-seq、Hi-C、4C-seq等多组学技术，系统揭示了HDAC3 抑制性复合体的遗传机制和细胞功能。这些研究有助于深入理解疾病发展过程中炎症因子的调控网络，对临床治疗具有重要指导意义。他的研究发现核受体共调因子在表观修饰、代谢、炎症调控以及代谢病的发展中具有重要潜力。他曾在2021年获得欧洲糖尿病学会青年科学家荣誉称号，并主持了一项欧盟基金项目。相关文章以第一或通讯作者发表在Cell Metabolism（2025）、Cell Death & Disease (2025）、 Nucleic Acids Research（2023, 2025）、Advanced Science（2024）、Molecular Cell（2021）、FASEB Journal (2019）、Frontiers in Endocrinology（2023）和STAR Protocols（2022）上。此外, 团队广泛与国内外学者开展联合研究，合作文章发表于Science Advances （2024）、Nature（2023）、The Journal of Clinical Investigation （2023）、Nature Communications （2019）、Cell Reports （2018）、和Nature Medicine（2016）上。

      营养感知是机体维持代谢稳态的中枢枢纽,包括胰岛素–胰高血糖素轴、PPAR–SREBP、AMPK–mTOR轴、轴分别感知葡萄糖、脂肪酸与氨基酸的供给状态，并在进食与空腹之间精确切换合成代谢与分解代谢。脂肪组织承担“储存与信号”双重功能。骨骼肌作为能量代谢“燃烧与合成”的关键枢点，胰岛素与运动分别驱动GLUT4转位、糖原合成与脂肪酸氧化，氨氨酸触发的mTORC1活化促进蛋白合成。肝脏为“代谢调度中心”，在胰岛素与胰高血糖素以及节律因子的配合下实现糖原合成与糖异生的动态切换，SREBP与PPARs分别主导从头脂肪生成与β氧化/酮体生成。营养平衡过程中，各器官能精准的协调组织代谢稳态并介导脂质的储存、运输; 糖代谢和氨基酸代谢的动态平衡。营养感知失衡是所以代谢性疾病发生和发展的基础，包括肥胖、糖尿病以及重度营养不良等疾病过程。

      虽然过去的几十年间，研究者对生理过程中营养感知和调控进行了持续的研究和探索，在肥胖等领域取得了突出的研究成果，并诞生了众多靶向肥胖和慢性代谢性疾病的药物靶点，然而，针对消耗性疾病，尤其是重度营养不良导致的组织消耗过程中营养维持机制和逆转方法仍然缺乏深刻认识。这使得多种消耗性疾病过程，如肿瘤恶液质、慢性心衰、慢性肾病等疾病导致的进行性组织流失和体重降低，长期缺乏有效的医学治疗方案。课题组在组织营养感知领域的科研训练和积累，将致力于回答消耗性组织流失过程中，探究以下几个科学问题: 1）维持组织功能稳态所必需的最低代谢基线为何、如何被重设?；2）代谢调控与神经（含内分泌-免疫轴）之间的因果关系与信息通路；3）靶向糖、脂质与氨基酸代谢能否分层、精准地改善组织消耗与器官衰竭? 我们计划结合多组学与代谢通量测定、神经环路示踪与干预、跨物种模型与前瞻性队列，鉴定可成药靶点与生物标志物，开发营养配方优化、代谢调节药物与神经调控等组合策略，力求建立可推广的转化路径，缓解营养不应与极端厌食症、渐冻症等重大健康问题，提升患者生活质量并降低老龄化带来的医疗与家庭负担。

1. 江苏省免疫学会，衰老和免疫分会常务理事

2. 太阳成城集团tyc234cc古天乐青年促进会委员

2. Phenomics 杂志青年编委(复旦大学主办)

3. Frontiers in Endocrinology 特约编辑

1. Lian P, Li L, Lu R, Zhang B, Wazir J, Gu C, Ma B, Pu W, Cao W, Huang Z#, Su Z#, Wang H#. S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis. Cell Death & Disease. 2025 Jan 20;16(1):31. 

2. Kai Lin, Lulu Wei1, Ranran Wang, Li Li, Shiyu Song, Fei Wang, Meiwei He, Wenyuan Pu, Jinglin Wang, Junaid Wazir, Wangsen Cao, Xiaozhong Yang, Eckardt Treuter, Rongrong Fan, Yongxiang Wang#, Zhiqiang Huang#, Hongwei Wang#. Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1. Cell Metabolism. 2025 Dec 20:S1550-4131(24)00413-3. Cover Story

3. Astradeni Efthymiadou, Chaode Gu, Cheng Wang, Hongwei Wang, Ziyi Li, Oihane Garcia-Irigoyen, Rongrong Fan, Eckardt Treuter, Zhiqiang Huang#. SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages, Nucleic Acids Research, 2025,  53, (17). 

4. Zhiqiang Huang, Ning Liang, Saioa Goni, Anastasios Damdimopoulos, Cheng Wang, Raphaelle Ballaire, Jennifer Jager, Henri Niskanen, Hongya Han, Tomas Jakobsson, Adrian P Bracken, Myriam Aouadi, Nicolas Venteclef, Minna U Kaikkonen, Rongrong Fan, Eckardt Treuter. The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages. Molecular Cell, 2021, 81:953–968 e959.  Featured Articles.

5. Zhiqiang Huang, Astradeni Efthymiadou, Ning Liang, Rongrong Fan, Eckardt Treuter. Antagonistic action of GPS2 and KDM1A at enhancers governs alternative macrophage activation by interleukin 4. Nucleic Acids Research, 2023, 51:1067-1086.

6. Zhiqiang Huang#, Cheng Wang, Eckardt Treuter, Rongrong Fan#. An optimized 4C-seq protocol based on cistrome and epigenome data in the mouse RAW264.7 macrophage cell line. STAR protocols, 2022, 3:101338.

7. Zhiqiang Huang#, Hengmi Cui. Functional epigenetic regulation in metabolic diseases. Frontiers in Endocrinology, 2023, 14:1190693.

8. Zhiqiang Huang, Ning Liang, Anastasius Damdimopoulos, Rongrong Fan, Eckardt Treuter. G protein pathway suppressor 2 (GPS2) links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. FASEB Journal, 2019, 33:1631–1643.  Cover Story

9. Vladimir J*, Tabraue C*, Huang Z*, Orizaola MC, Martin-Rodríguez P, Steffensen KR, Zapata JM, Boscá L, Tontonoz P, Alemany S, Treuter E, Castrillo A. Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Advanced Science (Weinh). 2024 May;11(20): e2307201.

10. Ruan B, Dong J, Wei F, Huang Z, Yang B, Zhang L, Li C, Dong H, Cao W, Wang H, Wang Y. DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis. Bone Research. 2024 Dec 2;12(1):68.

11. Ma B, Gu C, Lu R, Lian P, Wang W, Huang Z#, Su Z#, Wang H#. Inhibition of KPNA2 by ivermectin reduces E2F1 nuclear translocation to attenuate keratinocyte proliferation and ameliorate psoriasis-like lesions. International Immunopharmacology. 2024 Dec 25;143(Pt 1):113360.

12. Li L, Wazir J, Huang Z, Wang Y, Wang H*. A comprehensive review of animal models for cancer cachexia: Implications for translational research. Genes Disease. 2023 Sep 13;11(6):101080.

13. Gu C, Huang Z, Sun Y, Shi S, Li X, Li N, Liu Y, Guo Z, Jin N, Zhao Z, Li X, Wang H*. Characterization of Human Immortalized Keratinocyte Cells Infected by Monkeypox Virus. Viruses. 2024 Jul 26;16(8):1206.

14. Ma C, Gu C, Lian P, Wazir J, Lu R, Ruan B, Wei L, Li L, Pu W, Peng Z, Wang W, Zong Y, Huang Z, Wang H*, Lu Y*, Su Z*. Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. Cell Death & Disease. 2023 Nov 25;14(11):768.

15. Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, Hu J, Tüksammel E, Cai H, Liang N, Xu X, Yang X, Schmidt S, Qiao X, Schlisio S, Strömblad S, Qian H, Jiang C, Treuter E, Bergo MO. Antioxidants stimulate BACH1-dependent tumor angiogenesis. Journal of Clinical Investigation. 2023 Oct 1;133(20): e169671.

16. Paredes A, Justo-Méndez R, Jiménez-Blasco D, Núñez V, Calero I, Villalba-Orero M, Alegre-Martí A, Fischer T, Gradillas A, Sant'Anna VAR, Were F, Huang Z, Hernansanz-Agustín P, Contreras C, Martínez F, Camafeita E, Vázquez J, Ruiz-Cabello J, Area-Gómez E, Sánchez-Cabo F, Treuter E, Bolaños JP, Estébanez-Perpiñá E, Rupérez FJ, Barbas C, Enríquez JA, Ricote M. γ-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023 Jun;618(7964):365-373.

17. Ludzki AC, Hansen M, Zareifi D, Jalkanen J, Huang Z, Omar-Hmeadi M, Renzi G, Klingelhuber F, Boland S, Ambaw YA, Wang N, Damdimopoulos A, Liu J, Jernberg T, Petrus P, Arner P, Krahmer N, Fan R, Treuter E, Gao H, Rydén M, Mejhert N. Transcriptional determinants of lipid mobilization in human adipocytes. Science Advances. 2024 Jan 5;10(1): eadi2689.

18. Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nature Communications. 2019 Apr 11;10(1):1684.

19. Fan R, Toubal A, Goñi S, Drareni K, Huang Z, Alzaid F, Ballaire R, Ancel P, Liang N, Damdimopoulos A, Hainault I, Soprani A, Aron-Wisnewsky J, Foufelle F, Lawrence T, Gautier JF, Venteclef N, Treuter E. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nature Medicine. 2016 Jul;22(7):780-91.

20. Drareni K, Ballaire R, Barilla S, Mathew MJ, Toubal A, Fan R, Liang N, Chollet C, Huang Z, Kondili M, Foufelle F, Soprani A, Roussel R, Gautier JF, Alzaid F, Treuter E, Venteclef N. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Reports. 2018 Sep 11;24(11):2957–2971.e6.

* co-first author; # co-corresponding author

1. Fundamental Research Funds for the Central Universities (No. 0214/14380538),

2. Fundamental Research Funds for the Central Universities (No. 0214/14380550),

3. Team building and start-up funds of Nanjing University (No. 0214/14912217),

4. National Natural Science Foundation of China (No. 82571040),

5. Jiangsu Province Basic Research Funds (No. BK20251988).

1.    EFSD/Lilly Young Investigator Research Award (2021), Karolinska Institute